RNAconTest: comparing tools for noncoding RNA multiple sequence alignment based on structural consistency
نویسندگان
چکیده
منابع مشابه
ProbCons: Probabilistic consistency-based multiple sequence alignment.
To study gene evolution across a wide range of organisms, biologists need accurate tools for multiple sequence alignment of protein families. Obtaining accurate alignments, however, is a difficult computational problem because of not only the high computational cost but also the lack of proper objective functions for measuring alignment quality. In this paper, we introduce probabilistic consist...
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Motivation: An apparent paradox in computational RNA structure prediction is that many methods, in advance, require a multiple alignment of a set of related sequences, when searching for a common structure between them. However, such a multiple alignment is hard to obtain even for few sequences with low sequence similarity without simultaneously folding and aligning them. Furthermore, it is of ...
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ژورنال
عنوان ژورنال: RNA
سال: 2020
ISSN: 1355-8382,1469-9001
DOI: 10.1261/rna.073015.119